The first Seminary in Malta was opened by Bishop Cocco Palmieri on 25 March 1703 for the first six students. This Seminary was in the old capital of Mdina where today we find the Cathedral Museum.

In the mid 18th Century, the Seminary was transferred to St. Calcedonius in the suburb of Floriana where it stayed till 1977.

The present complex housed the Mater Admirabilis Training College. The foundation stone of the building was laid in 1952 by the Governor Gerald Creasy and was opened in 1954 by Queen Elizabeth II. When this college was suppressed in 1973, Archbishop Mercieca opted to transfer the Seminary to this venue. The Minor Seminary moved on the 15th November 1977 whereas the Major Seminary in September 1978. During the years between 1978-88 it also housed the Faculty of Theology.

The main chapel of the Seminary was consecrated on the 31st May 1955 by Archbishop Michael Gonzi. The new altar was consecrated on the 20th October 1988.

The statue of Christ the Redeemer was paid by each Maltese giving a penny. It was originally placed in 1901 on the dome of the Chapel of Our Lady “Tal-Virtù”. However it was taken down in 1935 because of the damaged dome of the said chapel. In 1984 it was restored and brought into the Seminary grounds.